Comments on: June 1st ‘GUT FOOD SIGNALING – PART 2 of 3’ Zoom Presentation plus Q&A https://metabolicduo.com/june-1st-gut-food-signaling-part-2-of-3-zoom-presentation-plus-qa/ Hard Science - Simple Solutions Tue, 15 Aug 2023 20:54:13 +0000 hourly 1 https://wordpress.org/?v=6.6.1 By: Igor Banovic https://metabolicduo.com/june-1st-gut-food-signaling-part-2-of-3-zoom-presentation-plus-qa/#comment-151 Tue, 15 Aug 2023 20:54:13 +0000 https://metabolicduo.com/?p=180#comment-151 In reply to Igor Banovic.

Is it Gordan Lauc?

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By: Igor Banovic https://metabolicduo.com/june-1st-gut-food-signaling-part-2-of-3-zoom-presentation-plus-qa/#comment-150 Tue, 15 Aug 2023 20:49:13 +0000 https://metabolicduo.com/?p=180#comment-150 In reply to Ivor.

You’ve mentioned him as part of the advisory team to the Croatian government during the whole COVID thing.

He is mentioned in the recording above (around 1:10:xx), regarding blood type and diet.

Frof. Lutz? Gordan? Gordon?

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By: Ivor https://metabolicduo.com/june-1st-gut-food-signaling-part-2-of-3-zoom-presentation-plus-qa/#comment-149 Tue, 15 Aug 2023 08:57:15 +0000 https://metabolicduo.com/?p=180#comment-149 In reply to Igor Banovic.

Oops Igor remind me/Gabor who that guy was again – a little more detail?

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By: Igor Banovic https://metabolicduo.com/june-1st-gut-food-signaling-part-2-of-3-zoom-presentation-plus-qa/#comment-146 Fri, 11 Aug 2023 19:10:12 +0000 https://metabolicduo.com/?p=180#comment-146 Hello, good sirs! This is great material, thank you!

Ivor, would you be so kind to write the name od the Dr. from Croatia? I’m from Croatia and would like to check out his work.

Thank you and keep up the “very good” work!

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By: Gabor https://metabolicduo.com/june-1st-gut-food-signaling-part-2-of-3-zoom-presentation-plus-qa/#comment-135 Tue, 04 Jul 2023 15:32:37 +0000 https://metabolicduo.com/?p=180#comment-135 In reply to Paul and Rachel Chandler.

Thank you for the suggestion, Rachel. We’re considering several options, and among them the incorporation of some of the lectures into an online training course. If that decision is made it would be counterproductive to prematurely release the lectures in question in PDF forms.

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By: Gabor https://metabolicduo.com/june-1st-gut-food-signaling-part-2-of-3-zoom-presentation-plus-qa/#comment-134 Tue, 04 Jul 2023 15:30:43 +0000 https://metabolicduo.com/?p=180#comment-134 In reply to William Schwartz.

Sorry for the late reply, quite some developments in my “professional life” recently.

There’s certainly more to metabolic damage than carbohydrate processing. If you watched all three parts it may have become more clear that food order, meal frequency, physical activity post meals, etc. also play a role. Not to mention factors not discussed in this series, such as air pollution, synthetic organic compounds (endocrine disrupters), bad sleep quality, noise, etc.
When thinking of the Japanese for example, two factors come to mind:
– there’s a traditional food order that puts plant roughage to the beginning of a meal then they continue with protein and fat rich food items and eat most of the rice and any sweets at the end.
– an old Japanese saying goes something like: climb a thousand steps after meals and you live to a hundred years.

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By: Paul and Rachel Chandler https://metabolicduo.com/june-1st-gut-food-signaling-part-2-of-3-zoom-presentation-plus-qa/#comment-121 Sat, 17 Jun 2023 12:42:17 +0000 https://metabolicduo.com/?p=180#comment-121 Hello Ivor and Gabor,
I’ve just returned to this session because I found it difficult to take in first time round. It’s really fascinating but I’m still struggling with all the abbreviations, mechanisms and research findings. There is so much going on in Gabor’s slides and the pastel colours also make it harder for our old eyes to read on a laptop (we’re travelling at the moment). It would be great if you could let us have them to download and print off.
Thanks,
Rachel

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By: William Schwartz https://metabolicduo.com/june-1st-gut-food-signaling-part-2-of-3-zoom-presentation-plus-qa/#comment-115 Sat, 10 Jun 2023 13:00:24 +0000 https://metabolicduo.com/?p=180#comment-115 In reply to Gabor.

Thanks, Gabor. No doubt heat (cooking) can break down food structure. What I wonder is what evidence we have comparing the detrimental hormonal effects of cooking with modern industrial processes such as milling flour and isolating sugars.

It’d be interesting to see comparisons, if they exist, of the hormonal effects of, say, cooked tubers, white rice, flour bread, fruit juice, etc. I’d like to think that pre-industrial processing is, in general, less harmful, or even beneficial (Schindler), but the reality may be different.

More generally I wonder why, mechanistically, you think cultures eating cooked starches, for example, can remain so lean and healthy, in contrast to cultures that have undergone the “nutrition transition” to industrially processed foods.

Thanks,
Bill

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By: Gabor https://metabolicduo.com/june-1st-gut-food-signaling-part-2-of-3-zoom-presentation-plus-qa/#comment-114 Tue, 06 Jun 2023 21:36:29 +0000 https://metabolicduo.com/?p=180#comment-114 In reply to William Schwartz.

The impact depends on starch structure and how it can be solubilized by cooking. From the hormonal response perspective, cooking is usually not inert, rather greatly accelerates digestibility. Just think of most industrial processes that involve cooking of starches despite the considerable cost of heat treatment. In the most sophisticated starch processing plants “cooking” temperature can reach 140 C (~285 F) at high pressure. And it’s worth it, because a single percent or so more starch can be converted to glucose.
So technically it’s definitely not correct to say that cooking is unquestionably harmless because of its role in human evolution. But again, cooking starchy or sugary foods can be a problem, cooking (not burning) protein and fat rich whole foods is not really.

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By: Gabor https://metabolicduo.com/june-1st-gut-food-signaling-part-2-of-3-zoom-presentation-plus-qa/#comment-113 Tue, 06 Jun 2023 21:29:14 +0000 https://metabolicduo.com/?p=180#comment-113 In reply to Jonathan Phillips.

Some caution has to be expressed in connection with big hunks in physiology from the appearance of a nutrient/compound in the gut and systemic metabolism. Depending on the type of the compound in question, several tissues have a pass before systemic availability. SCFA go directly to the liver, and their hepatic metabolism is not uniform at all. There seems to be no upper threshold for systemic release of acetate, but butyrate clearance is strictly regulated. See https://academic.oup.com/jn/article/145/9/2019/4644344
That’s likely due to the strong signaling effects of butyrate which acetate doesn’t have.
Acetate is also a substrate for lipogenesis, so it can contribute to lipid storage in some circumstances. High colonic levels signal microbial dysbiosis.

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