Comments for Metabolic Duo https://metabolicduo.com Hard Science - Simple Solutions Fri, 18 Apr 2025 13:18:36 +0000 hourly 1 https://wordpress.org/?v=6.8 Comment on MET DUO REPLAY April 17th – The Controversial LMHR Study Results by Ivor https://metabolicduo.com/met-duo-replay-april-17th-the-controversial-lmhr-study-results/#comment-471 Fri, 18 Apr 2025 13:18:36 +0000 https://metabolicduo.com/?p=377#comment-471 17:04:14 From Michael Delany : Best wishes Gabor 17:04:27 From Sameer Dossani : If anyone’s interested in my take on this study. More a response to the haters: https://www.sameerdossani.net/blog/LMHR 17:05:10 From Mary Murphy : Cool, Sameer. 17:05:32 From Moira Newiss The Brain Energy Reboot Expert : Reacted to "If anyone’s interest..." with 👏 17:18:07 From Sameer Dossani : Bob, the criticism are all using data from other centres to say that these were fast progressors 17:22:42 From S9061797 : 1 year isn't enough of course but the key endpoint for most of us is all-cause mortality! 17:24:48 From Moira Newiss The Brain Energy Reboot Expert : I can't seem to find any of the supplementary data, there is nothing there under the Supplementary Data heading. https://www.jacc.org/doi/10.1016/j.jacadv.2025.101686 17:25:43 From Sameer Dossani : Replying to "I can't seem to find..." They released the total plaque volume change on twitter. The number 18 seems to be the one that people are challenged by. 17:26:13 From Moira Newiss The Brain Energy Reboot Expert : Are you saying that the before and after measurements are not really comparable? 17:26:43 From Sameer Dossani : Replying to "Are you saying that ..." No, he’s saying that you can’t take data from one study and make conclusions about another study. 17:27:14 From Moira Newiss The Brain Energy Reboot Expert : Replying to "Are you saying that ..." Yes, I got that but I thought he was suggesting the other too - good to know not! 17:27:37 From S9061797 : Replying to "Are you saying that ..." ... but n=100 doesn't help - hence the fairly low quality of fit even with baseline plaque? 17:30:57 From Sameer Dossani : Replying to "Are you saying that ..." @S9061797 N=100 doesn’t mean that it’s meaningless. Maybe it can’t answer all the questions, but it does answer some. 17:33:20 From Sameer Dossani : Statins increase NO signalling I believe. 17:34:02 From Mary Murphy : sharryedwards@gmail.com is a guest suggestion. Ivor, it's okay to kick this can down the road. I just include it in the chat so that's it's available should you and Gabor decide to have her for a guest. 17:36:26 From Moira Newiss The Brain Energy Reboot Expert : But there are many risk factors for atherosclerosis... 17:37:54 From Sameer Dossani : I would challenge that a little. The question is whether high ApoB as an isolated variable is inherently athersclerotic. This is the only population within which this question can be tested. 17:40:16 From Idan : Why is it absurd that molecules made by your body can harm you in the long term? 17:42:16 From Ivor Cummins : Nail on head Malcolm. I used to always share this comparative analysis (KT) exemplar to help people stay within the rational/logical realm. Professor Karl Popper would be laughing in his grave at this one, based on his logical asymmetry of proof rules. This study kinda ended it for me. The Tsimane had broadly the same ApoB levels as the Western population, while they demonstrate the lowest CVD on the planet (the Westerners having the highest CVD on the planet): And yes the worst Westerners tend to have higher Apob, sure. Because it is a great (but fallible) proxy for Hyperinsulinemia - see here for one example: https://thefatemperor.com/2015-5-5-hilarious-apob-now-being-used-as-predictor-of-insulin-resistance-cholesterol-lchf/ Comparative Analysis and tools of logic....ain't just for Measles! 17:43:12 From Sameer Dossani : Replying to "Why is it absurd tha..." You’re kidding right? The human body has millions of years behind it all geared towards one thing - survival. It’s possible that our bodies would want to kill us, but it’s certainly not the null hypothesis. You would need a lot of evidence to support such a hypothesis. And it just doesn’t exist. 17:43:24 From Marion Paul - Saskatchewan, Canada : How long does it take for plaque to calcify? 17:45:07 From S9061797 : Replying to "Why is it absurd tha..." Devils advocate - some people make an awful lot of insulin. Short term "firefighting" can cause long term issues in some cases. Pulling Calcium out of bones might be another? 17:46:13 From Sameer Dossani : Replying to "Why is it absurd tha..." But this is in the context of modern diets and modern living. People outside of that context don’t have these issues, or maybe just in really odd genetic abnormalities. 17:54:17 From Sameer Dossani : These issues with the imaging is why they got Matthew Buddoff in the first place! He’s the damn expert!]]> Group chat: 17:03:04 From Sameer Dossani : Hi everyone. Sorry to hear about your wife’s health issues Gabor. And the lack of sleep.
17:03:29 From Mary Murphy : Ditto.
17:04:10 From Mary Murphy : 👋
17:04:14 From Michael Delany : Best wishes Gabor
17:04:27 From Sameer Dossani : If anyone’s interested in my take on this study. More a response to the haters: https://www.sameerdossani.net/blog/LMHR
17:05:10 From Mary Murphy : Cool, Sameer.
17:05:32 From Moira Newiss The Brain Energy Reboot Expert : Reacted to “If anyone’s interest…” with 👏
17:18:07 From Sameer Dossani : Bob, the criticism are all using data from other centres to say that these were fast progressors
17:22:42 From S9061797 : 1 year isn’t enough of course but the key endpoint for most of us is all-cause mortality!
17:24:48 From Moira Newiss The Brain Energy Reboot Expert : I can’t seem to find any of the supplementary data, there is nothing there under the Supplementary Data heading. https://www.jacc.org/doi/10.1016/j.jacadv.2025.101686
17:25:43 From Sameer Dossani : Replying to “I can’t seem to find…”

They released the total plaque volume change on twitter. The number 18 seems to be the one that people are challenged by.
17:26:13 From Moira Newiss The Brain Energy Reboot Expert : Are you saying that the before and after measurements are not really comparable?
17:26:43 From Sameer Dossani : Replying to “Are you saying that …”

No, he’s saying that you can’t take data from one study and make conclusions about another study.
17:27:14 From Moira Newiss The Brain Energy Reboot Expert : Replying to “Are you saying that …”

Yes, I got that but I thought he was suggesting the other too – good to know not!
17:27:37 From S9061797 : Replying to “Are you saying that …”

… but n=100 doesn’t help – hence the fairly low quality of fit even with baseline plaque?
17:30:57 From Sameer Dossani : Replying to “Are you saying that …”

@S9061797 N=100 doesn’t mean that it’s meaningless. Maybe it can’t answer all the questions, but it does answer some.
17:33:20 From Sameer Dossani : Statins increase NO signalling I believe.
17:34:02 From Mary Murphy : sharryedwards@gmail.com is a guest suggestion. Ivor, it’s okay to kick this can down the road. I just include it in the chat so that’s it’s available should you and Gabor decide to have her for a guest.
17:36:26 From Moira Newiss The Brain Energy Reboot Expert : But there are many risk factors for atherosclerosis…
17:37:54 From Sameer Dossani : I would challenge that a little. The question is whether high ApoB as an isolated variable is inherently athersclerotic. This is the only population within which this question can be tested.
17:40:16 From Idan : Why is it absurd that molecules made by your body can harm you in the long term?
17:42:16 From Ivor Cummins : Nail on head Malcolm.

I used to always share this comparative analysis (KT) exemplar to help people stay within the rational/logical realm. Professor Karl Popper would be laughing in his grave at this one, based on his logical asymmetry of proof rules. This study kinda ended it for me. The Tsimane had broadly the same ApoB levels as the Western population, while they demonstrate the lowest CVD on the planet (the Westerners having the highest CVD on the planet):

And yes the worst Westerners tend to have higher Apob, sure. Because it is a great (but fallible) proxy for Hyperinsulinemia – see here for one example: https://thefatemperor.com/2015-5-5-hilarious-apob-now-being-used-as-predictor-of-insulin-resistance-cholesterol-lchf/

Comparative Analysis and tools of logic….ain’t just for Measles!
17:43:12 From Sameer Dossani : Replying to “Why is it absurd tha…”

You’re kidding right? The human body has millions of years behind it all geared towards one thing – survival. It’s possible that our bodies would want to kill us, but it’s certainly not the null hypothesis. You would need a lot of evidence to support such a hypothesis. And it just doesn’t exist.
17:43:24 From Marion Paul – Saskatchewan, Canada : How long does it take for plaque to calcify?
17:45:07 From S9061797 : Replying to “Why is it absurd tha…”

Devils advocate – some people make an awful lot of insulin. Short term “firefighting” can cause long term issues in some cases. Pulling Calcium out of bones might be another?
17:46:13 From Sameer Dossani : Replying to “Why is it absurd tha…”

But this is in the context of modern diets and modern living. People outside of that context don’t have these issues, or maybe just in really odd genetic abnormalities.
17:54:17 From Sameer Dossani : These issues with the imaging is why they got Matthew Buddoff in the first place! He’s the damn expert!

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Comment on MET DUO REPLAY March 20th – Ivor on Hormonal and Weight Loss – Gabor on News Items by Ivor https://metabolicduo.com/met-duo-replay-march-20th-ivor-on-hormonal-and-weight-loss-gabor-on-news-items/#comment-470 Wed, 26 Mar 2025 17:23:18 +0000 https://metabolicduo.com/?p=371#comment-470 17:06:40 From Mary Murphy : 👋 17:09:59 From Dominic : A lot of Menopause blood test panels do not include testosterone, sadly. 17:22:11 From Mary Murphy : I do not believe blood type matters. Species type is all that matters. 17:22:21 From Dominic : Reacted to "I do not believe blo..." with 👍 17:24:25 From Dominic : Will reducing daily consumption, not lead to lower BMR? Is it better to pulse it? 17:25:14 From Mary Murphy : Forcing the lever will result in wrinkles. 17:25:48 From Nancy Whittington : Replying to "Forcing the lever wi..." 😄 17:26:54 From Moira Newiss The Brain Energy Reboot Expert : What about this study on women? https://pubmed.ncbi.nlm.nih.gov/37958602/ 17:27:32 From Moira Newiss The Brain Energy Reboot Expert : It was a great study taking women on keto diets and putting them back on a standard diet and health markers got worse. 17:29:06 From Dominic : Yes Ivor 17:31:32 From Mary Murphy : We missed you so much. It happens where I live too so I understood. 17:35:40 From Dominic : I saw that the butter also included cases where it included seed oils, so the butter wasn't exactly butter... "Science" 17:37:25 From Mary Murphy : Reminding our hosts that Sharry Edwards' email is sharryedwards@gmail.com. She'd be a great guest regarding frequencies. Everything is frequency. She has otoacoustic hearing which we all once had. 17:43:43 From Nancy Whittington : Ivor the measles death in Texas was from pneumonia not from measles.]]> Chat: 17:06:15 From Gabor Erdosi : 👋
17:06:40 From Mary Murphy : 👋
17:09:59 From Dominic : A lot of Menopause blood test panels do not include testosterone, sadly.
17:22:11 From Mary Murphy : I do not believe blood type matters. Species type is all that matters.
17:22:21 From Dominic : Reacted to “I do not believe blo…” with 👍
17:24:25 From Dominic : Will reducing daily consumption, not lead to lower BMR?
Is it better to pulse it?
17:25:14 From Mary Murphy : Forcing the lever will result in wrinkles.
17:25:48 From Nancy Whittington : Replying to “Forcing the lever wi…”

😄
17:26:54 From Moira Newiss The Brain Energy Reboot Expert : What about this study on women? https://pubmed.ncbi.nlm.nih.gov/37958602/
17:27:32 From Moira Newiss The Brain Energy Reboot Expert : It was a great study taking women on keto diets and putting them back on a standard diet and health markers got worse.
17:29:06 From Dominic : Yes Ivor
17:31:32 From Mary Murphy : We missed you so much. It happens where I live too so I understood.
17:35:40 From Dominic : I saw that the butter also included cases where it included seed oils, so the butter wasn’t exactly butter… “Science”
17:37:25 From Mary Murphy : Reminding our hosts that Sharry Edwards’ email is sharryedwards@gmail.com. She’d be a great guest regarding frequencies. Everything is frequency. She has otoacoustic hearing which we all once had.
17:43:43 From Nancy Whittington : Ivor the measles death in Texas was from pneumonia not from measles.

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Comment on MET DUO REPLAY Mar 6th LDL vs. Inflammation in CVD and Ivor Q and A by Ivor https://metabolicduo.com/met-duo-replay-mar-6th-ldl-vs-inflammation-in-cvd-and-ivor-q-and-a/#comment-469 Tue, 11 Mar 2025 12:53:50 +0000 https://metabolicduo.com/?p=368#comment-469 17:50:45 From Andrew Spadzinski : Watch out for the satellite photos Ivor, when you are stripped down … 17:50:53 From heather.rosa : Reacted to "Watch out for the sa..." with 😂 17:51:16 From Nancy : Reacted to "Watch out for the sa..." with 👍 17:55:10 From flora : where can we find your Ukraine video? 17:56:06 From Nancy : Reacted to "I listen to what Sar..." with 👍 17:57:07 From Ivor Cummins : https://www.youtube.com/watch?v=H-RnDNy0Iew 17:57:43 From Ivor Cummins : https://youtu.be/9lRN7Yt2eas 17:59:49 From Marion Paul - Saskatchewan, Canada : Thank you Ivor 17:59:50 From heather.rosa : thanks]]> 17:16:40 From Dominic : Gabor has frozen?
17:19:56 From Mary Murphy : When you asked for suggestions of guests, I didn’t think of the woman I’m about to suggest. Since then
I’ve wondered if we’d like to have her. Sharry Edwards promotes healing via frequency. Not everything she says
reflects her ability to recognize scientific proof because she’s not good at that.. The facts in her favor for me suggesting her are that frequency is everything and Sharry has otoacoustic hearing which humans all had at one time. Sharry took her otoacoustic hearing and spent many years, with the help of computer geeks, teaching computers how to do what her otoacoustic hearing allows her to do.
17:21:19 From heather.rosa : Hi everybody, now making vitamin D in the UK we have the sun back.
17:26:12 From Mary Murphy : If you choose to invite her (please don’t mention my opinion of her ability to distinguish between science and non-science) her email address is sharryedwards@gmail.com.
17:28:27 From flora : I have been looking at Autonomic Nervous Dysfunction.
17:31:58 From Mary Murphy : Ivor, since this session has become so casual, I want to take this opportunity to thank you for the video you released yesterday on Ukraine.
17:37:59 From heather.rosa : Sed rate https://www.ncbi.nlm.nih.gov/books/NBK557485/ cant tell you where it is and what is causing it
17:38:03 From Dominic : Dr Sara Pugh on Quantum Biology, Light, Mitochondrial health, etc… A lot of it goes over my head and how much it contributes to health compared to a good steak, I don’t know…
17:45:39 From Mary Murphy : I haven’t been sick in over 25 years so we all don’t get colds and flu.
17:45:55 From Mary Murphy : I listen to what Sara Pugh puts out (while I’m doing chores) and believe whatever resonates with me. She’s definitely worth listening to. Kudos for your steak remark although I’m told that the older we get (at least since we’ve all been damaged by lies) ground meat is the optimal choice.
17:48:08 From Linda : Replying to “I haven’t been sick …”

I rarely get sick either. It’s been over 6 years for a cold. I remember because we moved.
17:48:37 From Mary Murphy : Replying to “I haven’t been sick …”

Cool.
17:48:51 From heather.rosa : horizonal and naked Ivor!
17:48:56 From Dominic : Reacted to “I listen to what Sar…” with 👍
17:50:45 From Andrew Spadzinski : Watch out for the satellite photos Ivor, when you are stripped down …
17:50:53 From heather.rosa : Reacted to “Watch out for the sa…” with 😂
17:51:16 From Nancy : Reacted to “Watch out for the sa…” with 👍
17:55:10 From flora : where can we find your Ukraine video?
17:56:06 From Nancy : Reacted to “I listen to what Sar…” with 👍
17:57:07 From Ivor Cummins : https://www.youtube.com/watch?v=H-RnDNy0Iew
17:57:43 From Ivor Cummins : https://youtu.be/9lRN7Yt2eas
17:59:49 From Marion Paul – Saskatchewan, Canada : Thank you Ivor
17:59:50 From heather.rosa : thanks

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Comment on Met Duo Replay Feb 6th – Professor Vladimir Subbotin Masterclass in LDL Lies by Ivor https://metabolicduo.com/met-duo-replay-feb-6th-professor-vladimir-subbotin-masterclass-in-ldl-lies/#comment-468 Fri, 07 Feb 2025 12:32:02 +0000 https://metabolicduo.com/?p=358#comment-468 My talk in Denver pre-Covid! https://www.youtube.com/watch?v=alZ47dgu3LU

Email from Vladimir after session!

Hi Ivor, it was great to talk to you again!

These are article that I mentioned, one on transplant arteriosclerosis:

https://www.sciencedirect.com/science/article/pii/S1359644624003271

and another trying to connect all types of arterial neointimal formations in different diseases:

https://www.sciencedirect.com/science/article/pii/S0306987720313785

The irony is that most doctors/scientists likely also doubt the orthodox belief, but they know where money comes from. I admire your persistence, because I feel that nothing could be changed, probably I am wrong.

Lately I switched my effort toward the problem of life origin on Earth, and already published a couple articles.

https://www.liebertpub.com/doi/pdf/10.1089/ast.2021.0161

https://www.liebertpub.com/doi/full/10.1089/ast.2023.0011?

Talk to you soon.

Vladimir

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Comment on Met Duo Replay 9th Jan – Oxalates with Sally Norton special guest! by Mary Murphy https://metabolicduo.com/met-duo-replay-9th-jan-oxalates-with-sally-norton-special-guest/#comment-467 Wed, 22 Jan 2025 19:48:14 +0000 https://metabolicduo.com/?p=347#comment-467 A question was in the chat that said something to the effect of many carnivores report unusual plaque on the teeth. My comment on that was the plaque wasn’t from oxalates based on what I’d heard a carnivore dentist say. Seems I was partially wrong. Sally’s answer to the question in the chat was that oxalates being secreted by the body accumulate on the back of the incisors on the manible after we sleep.

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Comment on Sept 5th REPLAY: The Science of Sleep – and Stoicism! by Steve Limb https://metabolicduo.com/sept-5th-replay-the-science-of-sleep-and-stoicism/#comment-389 Thu, 19 Sep 2024 08:44:27 +0000 https://metabolicduo.com/?p=341#comment-389 The role of Tryptophan (about the 16 minute mark) seems important but I’m not clear on it’s effects and their mechanisms – what else do we know about that?

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Comment on Metabolic Duo 22nd Aug REPLAY – with Prof Thomas Seyfried ! by Aidan Waine https://metabolicduo.com/metabolic-duo-22nd-aug-replay-with-prof-thomas-seyfried/#comment-388 Wed, 28 Aug 2024 16:57:35 +0000 https://metabolicduo.com/?p=336#comment-388 In reply to William Hare.

Fascinating session, thanks!

Whatever the aetiology, Paul Jaminet’s new drug from Angiex–currently starting clinical trials–promises to target all solid tumors with unparalleled off-target low toxicity and may be a great complement to Prof Seyfried’s approach.

https://www.adcreview.com/clinical-trials-update/first-patient-dosed-in-first-in-human-trial-of-agx101-a-novel-adc-targeting-tm4sf1/

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Comment on Metabolic Duo 22nd Aug REPLAY – with Prof Thomas Seyfried ! by Claudia Wilkinson https://metabolicduo.com/metabolic-duo-22nd-aug-replay-with-prof-thomas-seyfried/#comment-387 Mon, 26 Aug 2024 10:32:41 +0000 https://metabolicduo.com/?p=336#comment-387 It would be really great if someone could do a DrBeen style (Dr Mobeen Syed on YouTube, great medical educator with skill at drawing out the mechanisms and excellent teacher) style series of lectures explaining his theory with diagrams from the first principles, including the experiments about transferring nuclei from cancer cells to normal cells and vice versa. This is too complicated to verbally explain to my friends with cancer. I would happily pay in the same way you pay for a book. DrBeen has, in the last few years, come around more to our way of thinking and may already have done something like this in his lecture series and Paul Marik has recently discovered the metabolic theory and mentions it in his book, Cancer Care which is mainly a compendium of useful information on repurposed drugs.
Here is a link to a Dhru Purohit podcast he did with the Hippocrates Research Foundation who are a small group of doctors who help patients interpret Thomas Seyfried’s work for their own cancers.
https://youtu.be/pm2ia_Nsfc8?si=9fmnP-tG4JMWPZjY

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Comment on Metabolic Duo 22nd Aug REPLAY – with Prof Thomas Seyfried ! by William Hare https://metabolicduo.com/metabolic-duo-22nd-aug-replay-with-prof-thomas-seyfried/#comment-386 Fri, 23 Aug 2024 21:49:16 +0000 https://metabolicduo.com/?p=336#comment-386 Excellent interview. Read Dr. Seyfried’s textbook twice when it first came out. Can you imagine if “all hands on deck” were put towards researching Metabolic cancer therapy aggressively? Thanks for doing interview. Bill

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Comment on MET DUO AUG 8TH: Male or Female Strength – Scientifically? An Olympian Question! by William Hare https://metabolicduo.com/met-duo-aug-8th-male-or-female-strength-scientifically-an-olympian-question/#comment-385 Wed, 21 Aug 2024 21:21:47 +0000 https://metabolicduo.com/?p=334#comment-385 Great discussion guys. Also, I think a future discussion about cancer with Thomas Seyfried would be excellent. Bill

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